생화학분자생물학회

	Sung Young Kim( palelamp@kku..ac.kr )
	2023-present	Professor, Department of Biochemistry, Konkuk University School of Medicine
	2021-2022	Visiting scholar, Department of Genetics, University of Cambridge
	2017-2022	Associate Professor, Department of Biochemistry, Konkuk University School of Medicine
	2013-2016	Assistant Professor, Department of Biochemistry, Konkuk University School of Medicine
	2011-2012	Assistant Professor, Department of Biochemistry, Gachon University School of Medicine
	2011	PhD, Department of Biochemistry, Seoul National University College of Medicine (M.Sc/Ph.D combined program)
	2008	MD, Konkuk University College of Medicine

Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics

Senescence compromises the essential role that the endothelium plays in maintaining vascular homeostasis, so promoting endothelial dysfunction and the development of age-related vascular diseases. Their biological and clinical significance calls for strategies for identifying and therapeutically targeting senescent endothelial cells. While senescence and endothelial dysfunction have been studied extensively, distinguishing what is distinctly endothelial senescence remains a barrier to overcome for an effective approach to addressing it. Here, we review the mechanisms underlying endothelial senescence and the evidence for its clinical importance. Furthermore, we discuss the current state and the limitations in the approaches for the detection and therapeutic intervention of target cells, suggesting potential directions for future research

Exp Mol Med. 2023 Jan;55(1):1-12. doi: 10.1038/s12276-022-00906-w.
https://pubmed.ncbi.nlm.nih.gov/36599934/