간행물

생화학분자생물학회입니다.


BMB Reports

The Complex Role of Extracellular Vesicles in HIV infection

  • 작성자

    Jung-Hyun Lee
  • 작성일자

    2023-07-20
  • 조회수

    970
Name: Jung-Hyun Lee ( jhlee1@uos.ac.kr )
2022-presentAssistant Professor , Department of Life Science, University of Seoul
2021-2022Project leader, Institute of Molecular Virology, Ulm University, Germany
2020-2020Research assistant Professor, Florida Research and Innovation, Cleveland Clinic, USA
2018-2020Postdoctoral scholar, Department of Microbiology, The University of Chicago, USA
2016-2018Junior group leader, Department of Dermatology, University Hospital of Erlangen, Germany
2014-2018Postdoctoral fellow, Department of Dermatology, University Hospital of Erlangen, Germany
2014Ph.D., Molecular virology and Cancer biology, Friedrich-Alexander-University Erlangen-Nürnberg, Germany

The Complex Role of Extracellular Vesicles in HIV infection

All cells release membrane vesicles called as extracellular vesicles (EVs) during normal physiological and abnormal pathophysiological conditions. Growing evidence has revealed the EVs as an important messenger in intercellular communication. EVs have emerging roles in cellular responses and modulation of immune responses during virus infection. EVs contribute to trigger antiviral responses to restrict virus infection and replication. On the other hand, the role of EVs in facilitation of virus spread and pathogenesis has been widely documented. Depending on the cell of origin, EVs carry effector functions from one cell to the other by horizontal transfer of their bioactive cargos, including DNA, RNA, proteins, lipids, and metabolites. The diverse constituents of EVs can reflect the altered states of cells or tissues during virus infection, thereby offering a diagnostic readout. The exchanges of cellular and/or viral components by EVs can inform their therapeutic potential of EVs for infectious diseases. This review provides recent advances of EVs to explore the complex roles of EVs during virus infection and the therapeutic potential, focusing on HIV-1.


BMB Rep. 2023 Jun;56(6):335-340. doi: 10.5483/BMBRep.2023-0073.
https://pubmed.ncbi.nlm.nih.gov/37291055/

 

[닫기]