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BMB Reports

Structural studies of serotonin receptor family

  • 작성자

    Kuglae Kim
  • 작성일자

    2023-11-27
  • 조회수

    652
Name: Kuglae Kim (klkim@yonsei.ac.kr)
2022-present Assistant Professor, Department of Pharmacy, College of Pharmacy, Yonsei University University
2017-2022 Postdoctoral research fellow, University of North Carolina at Chapel Hill, USA
2016-2017 Postdoctoral research fellow, Yonsei University, Korea
2007-2016 Ph.D., Department of Systemsbiology, Yonsei University, Korea

Structural studies of serotonin receptor family

Serotonin receptors, also known as 5-HT receptors, belong to the G protein-coupled receptors (GPCRs) superfamily. They mediate the effects of serotonin, a neurotransmitter that plays a key role in a wide range of functions including mood regulation, cognition and appetite. The functions of serotonin are mediated by a family of 5-HT receptors including 12 GPCRs belonging to six major families: 5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6 and 5-HT7. Despite their distinct characteristics and functions, these receptors’ subtypes share common structural features and signaling mechanisms. Understanding the structure, functions and pharmacology of the serotonin receptor family is essential for unraveling the complexities of serotonin signaling and developing targeted therapeutics for neuropsychiatric disorders. However, developing drugs that selectively target specific receptor subtypes is challenging due to the structural similarities in their orthosteric binding sites. This review focuses on the recent advancements in the structural studies of 5-HT receptors, highlighting the key structural features of each subtype and shedding light on their potential as targets for mental health and neurological disorders (such as depression, anxiety, schizophrenia, and migraine) drugs.


BMB Rep. 2023 Oct;56(10):527-536. doi: 10.5483/BMBRep.2023-0147
https://pubmed.ncbi.nlm.nih.gov/37817438/