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Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

  • 작성자

    Jaewon Ko
  • 작성일자

    2023-07-20
  • 조회수

    1062
Jaewon Ko( jaewonko@dgist.ac.kr )
2022-presentDirector, Center for Synapse Diversity and Specificity, DGIST, South Korea
2018-presentProfessor, Department of Brain Sciences, DGIST, South Korea
2017-2018Associate Professor, Department of Brain Sciences, DGIST, South Korea
2011-2017Assistant & Associate Professor, Department of Biochemistry, Yonsei University, South Korea
2008-2011Postdoctoral Researcher, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, USA
2007-2008Research Fellow, Department of Neuroscience, University of Texas Southwestern Medical Center, USA
2005-2007Researcher, KAIST, South Korea

Orchestration of synaptic functions by WAVE regulatory complex-mediated actin reorganization

The WAVE regulatory complex (WRC), composed of five components-Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300-is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans-synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

Exp Mol Med. 2023 Jun;55(6):1065-1075 doi: 10.1038/s12276-023-01004-1
https://www.ncbi.nlm.nih.gov/pubmed/37258575/

 

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