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Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

  • 작성자

    Hyukjin Lee
  • 작성일자

    2023-12-21
  • 조회수

    506
Hyukjin Lee( hyukjin@ewha.ac.kr )
2021-presentProfessor, College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
2017-2021Associate Professor, College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
2012-2017Assistant Professor, College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University
2010-2012Postdoctoral Associate, Koch Institute of Integrated Cancer Research, MIT, MA, USA
2009-2010Postdoctoral Fellow, Department of Chemistry, KAIST, Daejeon
2005-2009Ph.D, Biological Sciences (Drug delivery and Bioconjugate Chemistry), Korea Advanced Institute of Science and Technology, Daejeon, South Korea
2003-2004MS, Biomedical Engineering (Cartilage Tissue Engineering), Columbia University, NY, USA

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.

Exp Mol Med. 2023 Oct;55(10):2085-2096. doi: 10.1038/s12276-023-01086-x
https://www.nature.com/articles/s12276-023-01086-x