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Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

  • 작성자

    Keehoon Jung
  • 작성일자

    2023-12-21
  • 조회수

    524
Keehoon Jung( keehoon.jung@snu.ac.kr )
2018-presentAssistant Professor, Associate Professor, Seoul National University College of Medicine, Seoul, Republic of Korea
Department of Anatomy and Cell Biology / Biomedical Sciences
2013-2018Research Fellow, Harvard Medical School / Massachusetts General Hospital, Boston, MA
Edwin L. Steele Laboratories for Tumor Biology (Advisors: Profs. Rakesh K. Jain and Dai Fukumura)
2010-2013Research Fellow, Harvard Medical School / Massachusetts General Hospital, Boston, MA
Wellman Center for Photomedicine (Advisor: Prof. Andy Yun)
2005-2010Ph.D. in Biological Sciences and Biomedical Science & Engineering Program, KAIST (Advisor: Prof. Gou Young Koh)
2001-2005BS in Biological Sciences, KAIST

Normalization of the tumor microenvironment by harnessing vascular and immune modulation to achieve enhanced cancer therapy

Solid tumors are complex entities that actively shape their microenvironment to create a supportive environment for their own growth. Angiogenesis and immune suppression are two key characteristics of this tumor microenvironment. Despite attempts to deplete tumor blood vessels using antiangiogenic drugs, extensive vessel pruning has shown limited efficacy. Instead, a targeted approach involving the judicious use of drugs at specific time points can normalize the function and structure of tumor vessels, leading to improved outcomes when combined with other anticancer therapies. Additionally, normalizing the immune microenvironment by suppressing immunosuppressive cells and activating immunostimulatory cells has shown promise in suppressing tumor growth and improving overall survival. Based on these findings, many studies have been conducted to normalize each component of the tumor microenvironment, leading to the development of a variety of strategies. In this review, we provide an overview of the concepts of vascular and immune normalization and discuss some of the strategies employed to achieve these goals.

Exp Mol Med. 2023 Nov;55(11):2308-2319. doi: 10.1038/s12276-023-01114-w
https://pubmed.ncbi.nlm.nih.gov/37907742/