생화학분자생물학회

	KyeongJin Kim( kimkj@inha.ac.kr )
	2019-present	Assistant/Associate Professor, Department of Biomedical Sciences, Inha University
	2013-2019	Postdoctoral/Associate Research Scientist, Columbia University
	2010-2013	Postdoctoral Fellow, Sungkyunkwan University
	2000-2010	BS/MS/PhD, Department of Molecular Biology, Pusan National University

Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases

Posttranslational modification of proteins via ubiquitination determines their activation, translocation, dysregulation, or degradation. This process targets a large number of cellular proteins, affecting all biological pathways involved in the cell cycle, development, growth, and differentiation. Thus, aberrant regulation of ubiquitination is likely associated with several diseases, including various types of metabolic diseases. Among the ubiquitin enzymes, E3 ubiquitin ligases are regarded as the most influential ubiquitin enzymes due to their ability to selectively bind and recruit target substrates for ubiquitination. Continued research on the regulatory mechanisms of E3 ligases and their adaptors in metabolic diseases will further stimulate the discovery of new targets and accelerate the development of therapeutic options for metabolic diseases. In this review, based on recent discoveries, we summarize new insights into the roles of E3 ubiquitin ligases and their adaptors in the pathogenesis of metabolic diseases by highlighting recent evidence obtained in both human and animal model studies.

Exp Mol Med. 2023; 55(10): 2097-2014. doi: 10.1038/s12276-023-01087-w.
https://pubmed.ncbi.nlm.nih.gov/37779139/