간행물

생화학분자생물학회입니다.


EMM

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

  • 작성자

    Yeonseok Chung
  • 작성일자

    2023-12-21
  • 조회수

    739
Yeonseok Chung( tkkim@postech.ac.kr )
2014-presentAssistant/Associate/Full professor (tenured), Seoul National University
2010-2013Assistant professor, University of Texas HSC at Houston, TX, USA
2005-2009Postdoctoral fellow/Instructor, MD Anderson Cancer Center, TX, USA
1997-2003MS/PhD. Seoul National University, Seoul, Korea

CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the constituents of the predominant effector T-cell subset. However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies. Understanding the diverse roles and functions of effector CD8 T-cell subsets is crucial to discern the complex dynamics of immune responses in different disease settings. Furthermore, the development of immunotherapeutic approaches that specifically target and regulate the function of distinct CD8 T-cell subsets holds great promise for precision medicine.

Exp Mol Med. 2023 Nov;55(11):2287-2299. doi: 10.1038/s12276-023-01105-x
https://www.nature.com/articles/s12276-023-01105-x