생화학분자생물학회

	Name: Heung Kyu Lee ( heungkyu.lee@kaist.ac.kr )
	2016-present	Associate Professor, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea
	2009-2016	Assistant Professor, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea
	2009-2009	Postdoctoral Associate, Department of Immunobiology, Yale University, USA
	2004-2009	Ph.D., Department of Immunobiology, Yale University, New Haven, CT, USA

Dendritic cells in cancer immunology

Dendritic cells (DC), which consist of several different subsets, specialize in antigen presentation and are critical for mediating the innate and adaptive immune responses. DC subsets can be classified into conventional, plasmacytoid, and monocyte-derived DC in the tumor microenvironment, and each subset has been shown to play different roles. Because the role of intratumoral DCs to initiate antitumor immune responses with tumor-derived antigen presentation to T cells, DCs have been targeted in the treatment of cancer. By modulating the functionality of DCs, several DC-based immunotherapies have been developed, including administration of tumor-derived antigen and DC vaccines. In addition, DCs have been demonstrated to participate in the mechanisms of classical cancer therapies, such as radiation therapy and chemotherapy. Thus, regulating DCs is also important in improving current cancer therapies. Here, we will discuss the role of each DC subset in antitumor immune responses, and the current status of DC-related cancer therapies.

BMB Rep 2020 Dec 11;5201. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33298246/