생화학분자생물학회

	Name: Junho Choe ( jcho2711@hanyang.ac.kr )
	2019-present	Assistant Professor, Dept. of Life Science, College of Natural Sciences, Hanyang University, Seoul, Republic of Korea
	2014-2019	Postdoctoral Fellow, Stem Cell Program, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA
	2013-2014	Postdoctoral Fellow, School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
	2009-2013	Ph.D., Dept. of Biotechnology, Korea University, Seoul, Korea

Deciphering the molecular mechanisms of the Epitranscriptome in cancer

Post-transcriptional regulation is an indispensable cellular mechanism for controlling gene expression that dictates various cellular functions and cell fate decisions. Recently, various chemical modifications of RNA have been proposed to play crucial roles in the regulation of post-transcriptional gene expression, termed as “epitranscriptomics”. To date, more than 170 RNA modifications have been identified in almost all types of RNA. As seen with DNA modification, RNA modification-mediated gene expression regulation also be regulated by three groups of proteins; writers, readers and erasers. An increasing number of studies have revealed that abnormal regulation of RNA modification is closely associated with tumorigenesis. Notably, the molecular functions of a specific RNA modification often have opposite results. In this review, we highlight the current progress in elucidating the mechanisms of cancer development caused by numerous chemical modifications of various RNA species.


https://pubmed.ncbi.nlm.nih.gov/33298243/
BMB Rep. 2021 Feb;54(2):89-97.