생화학분자생물학회

	Yong-Yeon Cho (yongyeon@catholic.ac.kr)
	2020-present	Professor, College of Pharmacy, The Catholic University of Korea, South Korea
	2015-2020	Associate Professor, College of Pharmacy, The Catholic University of Korea, South Korea
	2011-2015	Assistant Professor, College of Pharmacy, The Catholic University of Korea, South Korea
	2005-2011	Research Assistant Professor, The Hormel Institute, University of Minnesota, USA
	2001-2005	Post-Doc, The Hormel Institute, University of Minnesota, USA
	1997-2000	PhD, Applied Genetic Engineering, Tohoku University, Japan

Stat2 Stability Regulation: an intersection between immunity and carcinogenesis

Since the majority of STAT2 studies have focused on interferon (IFN)-α/β (IFNα/β) signaling pathway-mediated host defense against viral infections, the role of STAT2 in cancer biology has been overlooked. The molecular mechanisms of ISGF3-mediated ISG gene expression provide the base foundation for activity regulation of STAT2 proteins but not protein quality control. The review article suggests that the activity of STAT2, a protein stimulated by molecular signaling systems to activate selected genes in ways that can lead to cancer, is regulated by factors controlling its rate of degradation. Furthermore, the review suggests that ultraviolet B is a novel environmental stimulus to enhance melanoma cell proliferation and colony growth. The physiological relevance between STAT2 protein levels, and stability regulation machineries is suggested for the modulation of not only immune responses, but also melanoma cell proliferation, and colony growth. Based on the data obtained from bioinformatic analysis and human clinical samples, the review article suggests a paradigm to investigate a new therapeutic drug development for skin cancer treatment.

Exp Mol Med. 2020, XXXXXXXX, doi: 10.1038/s12276-020-00506-6
https://www.ncbi.nlm.nih.gov/pubmed/32973222