생화학분자생물학회

	Name: Seung Hwan Lee ( lsh080390@cau.ac.kr )
	2022-present	Assistant Professor, Department of Life Science, Chung-Ang University
	2017-2022	Senior researcher, Korea Research Institute of Bioscience & Biotechnology (KRIBB)
	2014-2017	Postdoctoral research fellow, Institute for Basic Science, KOREA
	2008-2014	Ph.D., School of Interdisciplinary Bioscience & Bioengineering, Pohang University of Science and Technology (POSTECH), Korea

Recent advances in genome engineering by CRISPR technology

Due to the development of CRISPR technology, the era of effective editing of target genes has arrived. However, the offtarget problem that occurs when recognizing target DNA due to the inherent nature of CRISPR components remains the biggest task to be overcome in the future. In this review, the principle of inducing such unintended off-target editing is analyzed from the structural aspect of CRISPR, and the methodology that has been developed to reduce off-target editing until now is summarized.


BMB Rep. 2023 Dec 6:6038. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38053294/