생화학분자생물학회입니다.
Olfactory pathology in Alzheimer’s disease: a sign of ongoing neurodegeneration
작성자
Cheil Moon작성일자
2021-07-15조회수
220Name: Cheil Moon ( cmoon@dgist.ac.kr ) | ||
2009-present | Professor, Department of Brain & Cognitive Sciences, DGIST, ROK | |
2005-2009 | Assistant Professor, Department of Oral Anatomy & Neurobiology, Kyungpook National University, ROK | |
2005-2005 | Instructor, Johns Hopkins University, USA | |
1999-2005 | Research Associate, Johns Hopkins University, USA | |
1994-1999 | Postdoctoral research fellow, Johns Hopkins University, USA | |
1997-2004 | Ph.D., Department of Biology, Imperial College, UK. |
Olfactory pathology in Alzheimer’s disease: a sign of ongoing neurodegeneration
Olfactory neuropathology is a cause of olfactory loss in Alzheimer's disease (AD). Olfactory dysfunction is also associated with memory and cognitive dysfunction and is an incidental finding of AD dementia. Here we review neuropathological research on the olfactory system in AD, considering both structural and functional evidence. Experimental and clinical findings identify olfactory dysfunction as an early indicator of AD. In keeping with this, amyloid-β production and neuroinflammation are related to underlying causes of impaired olfaction. Notably, physiological features of the spatial map in the olfactory system suggest the evidence of ongoing neurodegeneration. Our aim in this review is to examine olfactory pathology findings essential to identifying mechanisms of olfactory dysfunction in the development of AD in hopes of supporting investigations leading towards revealing potential diagnostic methods and causes of early pathogenesis in the olfactory system.
BMB Rep 2021 Jun;54(6):295-304.
https://pubmed.ncbi.nlm.nih.gov/34162463/